Oxyfedrine L-form HCl

Research use only, not for human use.

Oxyfedrine L-form HCl (Ildamen) is a partial agonist at beta-adrenergic receptors and acts as a coronary vasodilator and cardiotonic agent.

Oxyfedrine hydrochloride, a vasodilator, is an orally active β-adrenoreceptor agonist. Oxyfedrine decreases the tonicity of coronary vessels. Oxyfedrine hydrochloride can be used in the research of cardiovascular disease.

Oxyfedrine (50 μM, 48 h) suppresses aldehyde dehydrogenase (ALDH) activity in HCT116 and HSC-4 cells.Oxyfedrine (50 μM, 48 h) acts as a sensitizer for GSH-depleting agents, and induces cell death in HCT116 and HSC-4 cells when with the drug combinations.Oxyfedrine (0-1 μg/mL) inhibits spontaneous myogenic activity in rat isolated portal vein.

Oxyfedrine (14 mg/kg, p.o., for 3-4 weeks) shows anti-anginal action in cats. Oxyfedrine (10 mg/kg, i.p., HCT116 cell xenograft mice) suppresses tumor growth when combined with sulfasalazine (SSZ, 350 mg/kg, i.p.).Oxyfedrine (1 mg/kg, i.v.) decreases the arterial and venous blood high blood viscosity (HBV) in ice water stress rats.

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GPCR/G Protein

Adrenergic Receptor

Adrenergic Receptor

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16777-42-7

349.85

C19H24ClNO3

>98% (HPLC)

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C(CCN[C@H]([C@H](O)C1=CC=CC=C1)C)(=O)C2=CC(OC)=CC=C2.Cl

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(-20℃)

With Ice Pack

≥ 2 years